- About our group
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- Computational Neuroscience Projects
- Complex Systems Projects
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- EURESIST - Project
- ICEA - Modelling goal-directed navigation of the rat
- Hippocampal oscillations
- Study of sensory systems
- Software package for complex network analysis
- Dynamics of evolving networks
- A populational model of hippocampus CA3 region slices
- Development of hippocampal place fields
- Hippocampal coding and dynamics
- Location dependent differences between somatic and dendritic IPSPs
- Olfaction and its underlying stochastic phenomena
- The role of self-excitation in the development of topographic order
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- CNS '15 Host Proposal
- IJCNN 11 Workshop
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- Minisymposium on Computational Aspects of Neurological and Psychatric Diseases
- Workshop on large scale random graphs
- Workshop on Cortico- Hippocampal dynamics: Navigation and Neuromodulation
- Joint Workshop on Neural Autonomous Robots
- Workshop on System Neuroscience
- Neuronhálózatok strukturális kérdései
- 7th Tamagawa Dynamic Brain Forum 2002
- Minisymposium on Computational Neuroscience
- Számítógepes neurológia konferencia, Problemák - Adatok - Modellek
- Budapest - Tampere Minisymposium on Computational Neurolgy
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Model-based source localization of extracellular action potentials
Traditional current source density calculation method (CSD) method allows calculation of neural current source distribution from the extracellular potential patterns, thus provides important information for neurophysiology. The traditional CSD method is based on strong physical foundations, but uses some assumptions, which can not hold for single cell activity. By this reason, traditional CSD method gives false results for single cell activity. A new, spike CSD (sCSD) method have been eveloped, directly designed for revealing current source density distribution of a single cell, during firing. This new method is based on the inverse solution of the Poisson-equation and were applied on extracellular spatial potential patterns of spikes.
The spikes were measured in cat primary auditory cortex witha 16 channel chronically implanted linear probe in vivo. Using our new method, many fine details of the spatio-temporal dynamics of spikes were uncovered. Dendritic back propa- gation was proven to be much more frequent than it was known before, it was observable in every cell. The speed of back propagation was typically different in the apical and basal directions. In contrast to the literature, forward propagation preceding the spikes was also observable. In perspective, this new method raises the possibility of identifying synaptic inputs, which causes a cell fire. |
Related PublicationsSomogyvári Z, Cserpán D, Ulbert I, Érdi P Localization of single cell current sources based on extracellular potentials patterns: the spike CSD method, European Journal of Neuroscience, Volume 36, Issue 10, pages 3299–3313, November 2012. Also see the cover page January 2013 Volume 37, Issue 1 Somogyvári Z, Cserpán D, Ulbert I, Érdi P Micro-Electric Imaging: Inverse Solution for Localization of Single Neuron Currents Based on Extracellular Potential Measurements Science Beyond Fiction, FET'11 The European Future Technologies Conference and Exibition, Procedia Computer Science, Volume 7, Pages 348-350, 2011 Somogyvári Z, Zalányi L, Ulbert I and Érdi P: Model-based source localization of extracellular action potentials. Journal of Neuroscience Methods 147(2) (2005) 126-137 |