Model-based source localization of extracellular action potentials

Traditional current source density calculation method (CSD) method allows calculation of neural current source distribution from the extracellular potential patterns, thus provides important information for neurophysiology. The traditional CSD method is based on strong physical foundations, but uses some assumptions, which can not hold for single cell activity. By this reason, traditional CSD method gives false results for single cell activity. A new, spike CSD (sCSD) method have been eveloped, directly designed for revealing current source density distribution of a single cell, during firing. This new method is based on the inverse solution of the Poisson-equation and were applied on extracellular spatial potential patterns of spikes.

The spikes were measured in cat primary auditory cortex with
a 16 channel chronically implanted linear probe in vivo. Using our new method, many fine
details of the spatio-temporal dynamics of spikes were uncovered. Dendritic back propa-
gation was proven to be much more frequent than it was known before, it was observable
in every cell. The speed of back propagation was typically different in the apical and basal
directions. In contrast to the literature, forward propagation preceding the spikes was also
observable. In perspective, this new method raises the possibility of identifying synaptic
inputs, which causes a cell fire.

Related Publications

Somogyvári Z, Cserpán D, Ulbert I, Érdi P Localization of single cell current sources based on extracellular potentials patterns: the spike CSD method, European Journal of Neuroscience, Volume 36, Issue 10, pages 3299–3313, November 2012. Also see the cover page January 2013 Volume 37, Issue 1
Somogyvári Z, Cserpán D, Ulbert I, Érdi P Micro-Electric Imaging: Inverse Solution for Localization of Single Neuron Currents Based on Extracellular Potential Measurements Science Beyond Fiction, FET'11 The European Future Technologies Conference and Exibition, Procedia Computer Science, Volume 7, Pages 348-350, 2011
Somogyvári Z, Zalányi L, Ulbert I and Érdi P: Model-based source localization of extracellular action potentials. Journal of Neuroscience Methods 147(2) (2005) 126-137