- About our group
- How to contact us
- Computational Neuroscience Projects
- Complex Systems Projects
- Past projects
- EURESIST - Project
- ICEA - Modelling goal-directed navigation of the rat
- Hippocampal oscillations
- Study of sensory systems
- Software package for complex network analysis
- Dynamics of evolving networks
- A populational model of hippocampus CA3 region slices
- Development of hippocampal place fields
- Hippocampal coding and dynamics
- Location dependent differences between somatic and dendritic IPSPs
- Olfaction and its underlying stochastic phenomena
- The role of self-excitation in the development of topographic order
- CNS '15 Host Proposal
- IJCNN 11 Workshop
- Past events
- Minisymposium on Computational Aspects of Neurological and Psychatric Diseases
- Workshop on large scale random graphs
- Workshop on Cortico- Hippocampal dynamics: Navigation and Neuromodulation
- Joint Workshop on Neural Autonomous Robots
- Workshop on System Neuroscience
- Neuronhálózatok strukturális kérdései
- 7th Tamagawa Dynamic Brain Forum 2002
- Minisymposium on Computational Neuroscience
- Számítógepes neurológia konferencia, Problemák - Adatok - Modellek
- Budapest - Tampere Minisymposium on Computational Neurolgy
- Education / Oktatás
- Lectures and News
Study of sensory systems
We are interested in the possible neural substrates of the high fidelity information transmission in sensory pathways. In particular, we ask questions about the interaction between various active conductances and plastic synaptic transmission at single neuron level.
Some of our modeling studies were motivated by the auditory brainstem nucleus, lateral superior olive (LSO):
We examined the possible functional roles of two hyperpolarization-activated conductances in lateral superior olive (LSO) principal neurons. Inputs of these LSO neurons are transformed into an output, which provides a firing-rate code for a certain interaural sound intensity difference (IID) range. Recent experimental studies have found pharmacological evidence for the presence of both the h conductance as well as the inwardly rectifying outward KIR conductance in the LSO. We addressed the question of how these conductances influence the dynamic range (IID versus firing rate). We used computer simulations of both a point-neuron model and a two-compartmental model to investigate this issue, and to determine the role of these conductances in setting the dynamic range of these neurons. The width of the dynamic regime, the frequency-current (f-I) function, first-spike latency, subthreshold oscillations and the interplay between the two hyperpolarization activated conductances are discussed in detail. The in vivo non-monotonic IID-firing rate function in a subpopulation of LSO neurons is in good correspondence with our simulation predictions. Two-compartmental model simulation results suggest segregation of h and KIR conductances on differentcompartments, as this spatial configuration could explain certain experimental results.
Here are some of our related publications to this project:
- Szalisznyó K.: Role of Hyperpolarization-activated Conductances in the Lateral Superior Olive: A Modeling Study; Journal of Computational Neuroscience (2006), 20(2):137-52.
- Szalisznyó K, Zalányi L: Role of hyperpolarization-activated conductances in the auditory brainstem; Neurocomputing 58-60 (2004) 401-407
Other works considered the effects of short term synaptic plasticity in sensory afferent pathways.
Afferent pathway of the electrosensory system in the weakly electric fish was used as biological motivation in some of these works. Related publications:
- Szalisznyó K. Longtin A, Maler L: Effect of synaptic dynamics on sensory coding and steady-state filtering properties in the electric sense, (in press, Biosystems).
- Szalisznyó K, Longtin, A and Maler, L: Altered sensory filtering and coding properties by synaptic dynamics in the electric sense; Neurocomputing 69 (2006) 1070-1075.
- Szalisznyó K, Tóth J: Temporal order of synaptic filters: Implications for F->D or D->F processes (presented at the CNS-2006 meeting)
- Zalányi L, Bazsó F, Érdi P: The effect of synaptic depression on stochastic resonance;Neurocomputing 38-40 (2001) 459-465
- Bazsó F, Zalányi L, Csárdi G: Channel Noise in Hodgkin-Huxley Model Neurons. Physics Letters A, 311/1 (2003) 13-20