Dynamic modeling of associative learning in schizophrenia

Schizophrenia is a complex disease of very diverse symptoms and mostly unknown causes. A possible underlying phenomenon is described by the "disconnection syndrome" hypothesis, when the control signal flow between cortical areas is impaired. Vaibhav Diwadkar conducted an fMRI study of associative learning with schizophrenia patients. We analyze this data using Dynamic Causal Models, which are inverted and compared with Bayesian techniques. We examine the differences in the causal connection patterns and strengths between healthy and schizophrenic subjects.

A poster about the project presented at the MITT 11 conference: pdf. Awarded with best poster award in Neural Disorders section.

A slide show presenting the project in Hungarian, targeted for general audience: pdf


People working on this project

Péter Érdi, Mihály Bányai, Vaibhav Diwadkar

Publications related to this project

Bányai M Az agyműködés hálózatai (Functional networks of the brain, in hungarian), Természet Világa 143(11):505-507, 2012.
M Bányai, B Ujfalussy, V Diwadkar and P Érdi. Impairments in the prefronto-hippocampal interactions explain associative learning deficit in schizophrenia. BMC Neuroscience 12(Suppl 1):93, 2011. doi:10.1186/1471-2202-12-S1-P93
P Érdi, M Bányai, B Ujfalussy, V Diwadkar. The schizophrenic brain: A broken hermeneutic circle. Some new insights and results. The 2011 International Joint Conference on Neural Networks (IJCNN), 2011. San José, CA, USA 3024 - 3027, 2011. doi:10.1109/IJCNN.2011.6033619
Bányai M, Diwadkar V, Érdi P. Model-based dynamical analysis of functional disconnection in schizophrenia. NeuroImage 58(3): 870-877, 2011. doi:10.1016/j.neuroimage.2011.06.046
CD, Gore, M Bányai, PM Gray, V Diwadkar, P Érdi. Pathological Effects of Cortical Architecture on Working Memory in Schizophrenia. Pharmacopsychiatry 43(Suppl 1)592-597
P. Érdi, B. Ujfalussy, V. Diwadkar: The schizophrenic brain: A broken hermeneutic circle Neural Network Word 19(5):413-427
VA Diwadkar, B Flaugher, T Jones, Zalányi L, Ujfalussy B, MS Keshavan, Érdi P.Impaired associative learning in schizophrenia: Behavioral and computational studies. Cognitive Neurodynamics 2(3):207-219 (2008)